Migraine refers to neurological diseases, in which intense headaches are recorded. In general, they are accompanied by such signs as nausea, vomiting, intolerance of sounds, fear of bright light. In the interval between attacks there are no symptoms. The main principle in the treatment of migraines is the prescription of medication. Often, for generic pain relief online review, it is enough to take analgesic as Panadol Extra generic or non-steroidal anti-inflammatory drugs. Among the most modern preparations, people use triptans. This is medicine, which relieves the patient of the headache due to interaction with the receptors of the brain. One of known triptans is Maxalt (Rizatriptan) used by many people.
Maxalt is widely spread anti migraine drug
Individuals buy Maxalt for relief of a migraine attack with or without an aura. The mechanism of action of triptans is directed both at relief of pain during an attack, and at work to eliminate the symptoms of accompanying migraines. Directions of action:
-constriction of the cerebral vessels, as a consequence of the arrest of a pain attack, while the remaining vessels have virtually no effect on these preparations;
-drugs have anti-inflammatory effect – reduce swelling, pressing on the nerve endings, which also reduces pain;
-act depressingly on the excited trigeminal nerve – this reduces its pain sensitivity.
What are the advantages of having medications for migraine? Preparations act quickly, remove pain and symptoms. Except of this preparation you can take another one for migraine as Panadol Extra medicine.
Application of Maxalt
When administered orally, a single Maxalt dosage is 10 mg. If the headache resumes after arresting the initial attack, it can be taken again. The daily dose is 30 mg, the interval between dosages at least 2 hours. In patients receiving propranolol, it is recommended to use medicament in a single dose of 5 mg, a daily dosing of not more than 15 mg. How long does Maxalt stay in your system? If patient use medication for a long time, it is necessary to check heart function using ECG. The effectiveness of repeated admission for arresting the same attack in the absence of effect from the initial dose has not been studied in controlled studies. Patients with a risk of developing CHD (including with diabetes, smoking, the presence of a family history of severe CHD) before starting treatment with the drug should conduct a study of the state of the cardiovascular system. Between the doses of Maxalt migraine medicine and Ergotamine preparations, an interval of at least 6 hours should be observed.
Collateral effects with taking of Maxalt
There is possible dizziness, drowsiness, weakness, fatigue, chest pain, abdominal pain, palpitations, nausea, vomiting, dry mouth, diarrhea, indigestion, thirst, neck pain, muscle stiffness, a feeling of heaviness and stiffness in the muscles, muscle weakness , headache, decreased mental activity, insomnia, hyperesthesia, tremor, ataxia, nervousness, disorientation, cutaneous erythema, pruritus, increased sweating, blurred vision, hot flashes; rarely – fainting, hypertension
Do not apply Maxalt
Possible contra-indications are:
– established ischemic heart disease, including angina pectoris, myocardial infarction in history, documented asymptomatic IHD;
– suspected ischemic heart disease;
-simultaneous therapy or a period of less than 2 weeks after the end of treatment with MAO inhibitors;
– hypersensitivity to active ingredient Rizatriptan.
Do not use in patients with basilar or hemiplegic migraine, with a headache unusual for migraine headaches.
Maxalt while pregnant and lactation
Adequate and well-controlled studies of the safety of medicine in pregnancy have not been conducted, so the application is only possible in cases of extreme necessity. Application in the lactation period is not recommended, as it is not known whether Maxalt is excreted in human breast milk.
Application in old age
Clinical experience with Maxalt in elderly patients is limited.
Application for children
The safety of anti migraine drug in pediatrics has not been studied, therefore, use in patients under 18 years of age is not recommended.
Some recommendations for Maxalt
Do not use in patients with basilar or hemiplegic migraine, with a headache untypical for migraine. It should be used only in patients with established diagnosis of migraine who buy Maxalt online. Patients with a risk of developing coronary artery disease (including arterial hypertension, diabetes, smoking, having a family history of severe coronary artery disease) before starting treatment with rizatriptan should conduct a study of the state of the cardiovascular system. People should avoid Maxalt and alcohol using together. It can be used no earlier than 2 weeks after the end of treatment with MAO inhibitors.
Maxalt drug interactions
With the simultaneous use of serotonin 5-HT1 receptor agonists, there is a risk of additive hyper stimulation of serotonin 5-HT1 receptors. When used simultaneously with MAO inhibitors, a significant increase in the concentration of active substance in the blood plasma is possible; with nitrates – there is a risk of developing spasm of the coronary arteries. With combined use with propranolol drug concentration in blood plasma increases.